Microcrystal electron diffraction (MicroED)

Microcrystal electron diffraction (MicroED) is a specialized cryo-electron microscopy (cryo-EM) technique used to determine atomic structures of small molecules or proteins from nanocrystals. It involves collecting electron diffraction data from tiny crystalline samples, often too small for traditional X-ray crystallography. By analyzing the diffraction patterns, high-resolution atomic models can be reconstructed, even from sub-micron-sized crystals. Facilities offering MicroED services manage all aspects of the process, including sample preparation, crystal screening, data collection, and structure determination.

For academic labs and industry clients, this service provides a streamlined solution for resolving structures of challenging samples, making it ideal for drug discovery, materials science, and fundamental research applications.