Single Particle Analysis

Single-particle processing is a cutting-edge cryo-electron microscopy (cryo-EM) technique used to determine the 3D structure of biological macromolecules at near-atomic resolution. It involves imaging thousands to millions of individual particles suspended in a thin layer of vitrified ice, capturing high-resolution 2D images from multiple angles. Advanced computational algorithms then align and average these images to reconstruct a detailed 3D structure of the molecule.

This service is ideal for researchers who want to outsource the technical aspects of data collection and analysis. Facilities offering this service handle everything from sample preparation and imaging to computational reconstruction of the 3D structure. For academic labs and industry clients, this means you provide the purified sample, and the facility delivers high-quality structural data tailored to your project’s needs—whether it’s advancing basic research, drug development, or biotechnology applications.