Cryo-Electron Tomography

Cryo-electron tomography (cryo-ET) is a powerful imaging technique that provides 3D reconstructions of biological samples in their native, near-physiological state. It involves capturing a series of 2D images at different tilt angles as the sample is rotated in the electron beam, which are then computationally aligned to create a detailed 3D model. Cryo-ET is particularly suited for studying the spatial organization of cellular structures, macromolecular complexes, and other heterogeneous samples.

This service is ideal for researchers who want to outsource the technical complexities of data collection and analysis. Facilities offering cryo-ET services manage every step, including sample preparation, tilt-series acquisition, and 3D reconstruction. For academic labs and industry clients, this means you provide the sample, and the facility delivers high-resolution tomograms, enabling you to visualize molecular arrangements and interactions critical to your research or development projects.